The potential impact of COIs on a research study can be reduced by:
(Click on each tab for further elaboration) (2,4)
Disclosing / declaring the conflict
- The first step to managing COIs is to declare them as soon as you become aware about them.
- You should declare COIs to:
- Your research team, so that you can work together to find effective coping strategies.
- The ethics committee, who can provide the necessary monitoring.
- Your research subjects, if you have important COIs that may affect their willingness to participate in your study.
- The public, when you publish your results.
Eliminating the conflict
For example:
- Stop investing in a company that may have financial gains through your study
- Delegating research tasks to those without a COI
Minimising the potential impact of the conflict
For example:
- Employing two people to perform data entry so that they can cross-check
- Using double blinding and randomisation to reduce potential biases
Monitoring the conflict
This could be in the form of:
- Self-monitoring within the team
- For example, ensuring that all team members know the research protocol clearly so that any violation of the protocol can be identified quickly.
- External monitoring
- For example, through inspections by the ethics committee and regulatory authorities.
It is important to note that the act of ‘concealing’ a COI may cause a greater backlash than the COI itself.
While different institutions may have different disclosure requirements (for example, you may only need to declare a financial COI of more than a certain value), it is best practice to declare all COIs that you are aware of, whether financial or non-financial.
Case study 1: Dr Wilson and Genovo Inc. →
The Canadian Institutes of Health Research (CIHR) and Queen’s University at Kingston. Module 7: Conflict of Interest. In: TCPS 2: CORE (Course on Research Ethics) [Internet]. Government of Canada; Available from: https://tcps2core.ca/welcome
Bell BA. Conflicts of Interest (RCR-Basic) (ID 16599). In: Johns Hopkins Bloomberg School of Public Health e-learning course - Responsible Conduct of Research (RCR) [Internet]. CITI program; Available from: https://www.citiprogram.org/index.cfm?pageID=14&languagePreference=English®ion=1