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Managing COIs

The potential impact of COIs on a research study can be reduced by:

(Click on each tab for further elaboration)  (2,4)

Disclosing / declaring the conflict

  • The first step to managing COIs is to declare them as soon as you become aware about them.
  • You should declare COIs to:
    • Your research team, so that you can work together to find effective coping strategies.
    • The ethics committee, who can provide the necessary monitoring.
    • Your research subjects, if you have important COIs that may affect their willingness to participate in your study.
    • The public, when you publish your results.

Eliminating the conflict

For example:

  • Stop investing in a company that may have financial gains through your study
  • Delegating research tasks to those without a COI

Minimising the potential impact of the conflict

For example:

  • Employing two people to perform data entry so that they can cross-check
  • Using double blinding and randomisation to reduce potential biases

Monitoring the conflict

This could be in the form of:

  • Self-monitoring within the team
    • For example, ensuring that all team members know the research protocol clearly so that any violation of the protocol can be identified quickly.
  • External monitoring
    • For example, through inspections by the ethics committee and regulatory authorities. 

It is important to note that the act of ‘concealing’ a COI may cause a greater backlash than the COI itself.

While different institutions may have different disclosure requirements (for example, you may only need to declare a financial COI of more than a certain value), it is best practice to declare all COIs that you are aware of, whether financial or non-financial.




Case study 1
: Dr Wilson and Genovo Inc. 

The Canadian Institutes of Health Research (CIHR) and Queen’s University at Kingston. Module 7: Conflict of Interest. In: TCPS 2: CORE (Course on Research Ethics) [Internet]. Government of Canada; Available from: https://tcps2core.ca/welcome

Bell BA. Conflicts of Interest (RCR-Basic) (ID 16599). In: Johns Hopkins Bloomberg School of Public Health e-learning course - Responsible Conduct of Research (RCR) [Internet]. CITI program; Available from: https://www.citiprogram.org/index.cfm?pageID=14&languagePreference=English®ion=1